EASTERN NAZARENE COLLEGE |
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MANY DIFFERENCES, ONE FAITH |
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About ENC | Chemistry | Dr. Wooster | Courses | CV | Research | Faith | |
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Background
SAM Attachment High Temperature |
Research, Dr.
Wooster
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I
am working on a protocol
for the attachment of electroactive molecules to the surface of
chemically modified electrodes based on the chemistry developed for
protein coupling. Specifically the use of N-Hydroxysulfosuccinimide
(sulfo-NHS) and
1-Ethyl-3-(3-Dimethylaminopropyl)-Carbodiimide Hydrochloride (EDC)
to promote the coupling of a carboxyl terminated alkane-thiol to an
electro-active compound with an amine functional group such as
dopamine.
The
electroactive headgroup I have chosen to study is the cobalt cage
complex [Co(diAMsar)]Cl3
shown here. This compound is appealing due to its terminal
amine groups and the electroactive cobalt center. The synthesis of
this compound is a two step process involving the conversion of
Cobalt tris ethylene diamine into the nitro terminated cage in the
presence of nitro-methane and formaldehyde.
In the second step, the Co(diNOsar)3+ is reduced in the
presence of zinc and hydrochloric acid to the desired [Co(diAMsar)]Cl3. This synthesis
although challenging, is feasible for an undergraduate student to
perform, and introduces them to a variety of synthetic methodologies
and skills. I have had an undergraduate student working with me for
2 summers who successfully completed the synthesis of [Co(diAMsar)]Cl3
and
is currently working on the EDC/NHS attachment scheme. p give us better insight into our world. |
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Eastern Nazarene College,
23 East Elm Avenue, Quincy, Massachusetts 02170
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